Anti-Aging Regimen Bundle | Circadia

Circadia by Dr. Pugliese was built on a single scientific conviction: that the skin operates on a biological clock, running protective processes during the day and shifting to repair and regeneration at night. Products aligned with that rhythm, specifically targeted to support the skin's nocturnal repair cycle, consistently outperform those that apply the same treatment at both times of day. The Anti-Aging Essentials Regimen Kit is the most complete expression of that conviction in a single retail package.
The kit opens with the Amandola Milk Cleanser, a creamy, non-foaming cleanser built around lactic acid and mandelic acid, both alpha hydroxy acids that function as tyrosinase inhibitors. Lactic acid stimulates glycosaminoglycan production, supporting the skin's own moisture matrix. Mandelic acid has additional antimicrobial and brightening properties particularly suited to aging and pigmented skin. Sweet almond milk provides nourishing conditioning. Oat protein delivers antioxidant and anti-irritant support. The result is a cleanser that actively treats the skin rather than simply removing impurities.
Serum 71 is Circadia's cornerstone anti-aging and brightening serum, used in the PM after cleansing. The formula combines tranexamic acid, a proven tyrosinase inhibitor that reduces the appearance of hyperpigmentation and melasma by blocking the enzymatic pathway that produces excess melanin, with azelaic acid, which provides additional brightening, pore-refining, and anti-inflammatory benefits. The next-generation copper peptide is Neodermyl (Methylglucoside Phosphate and Copper Lysinate/Prolinate), a patented copper-based ingredient clinically shown to stimulate collagen and elastin production more effectively than standard copper peptides. Magnesium Carboxymethyl Beta-Glucan is a second-generation beta-glucan with enhanced skin-fortifying and repair-stimulating activity. Applied consistently at night, Serum 71 addresses fine lines, discoloration, uneven texture, and loss of firmness simultaneously.
Cyto-Comm (Cyto-Comm Revitalizing Serum) is the regimen's cellular communication step, applied after Serum 71. The formula centers on Trifluoroacetyl Tripeptide-2, a specialized peptide that targets the process of glycation, the accumulation of advanced glycation end-products (AGEs) that cross-link collagen fibers, stiffening them and accelerating the visible signs of aging. Cyto-Comm detoxifies the skin from glycating agents, protects biomolecules from glycation-induced inflammation, and prevents the cell loss associated with elevated A.G.E. levels. Aminopropyl Ascorbyl Phosphate delivers a stable, water-soluble Vitamin C derivative to support antioxidant protection. Hyaluronic Acid provides immediate hydration. Osmanthus Fragrans Flower Extract contributes calming botanical support. Together, Serum 71 and Cyto-Comm address aging at both the structural level (collagen and elastin) and the molecular level (glycation), a dual-pathway approach that most single-serum anti-aging products can't replicate.
Revita-Cyte Complex (Revita-Cyte Complex Revitalizing Lotion) is the final step of the PM routine, a moisturizing complex that delivers advanced antioxidants, next-generation peptides, and mitochondrial-supporting ingredients that help firm the skin, improve radiance, and restore youthful resilience. It also supports optimal Vitamin D expression, a critical but often overlooked factor in skin cell communication and barrier integrity that diminishes with age. Applied last, it seals the regimen while continuing the active work of the serums beneath it.
Developed by Circadia, a professional-grade skincare brand founded by biochemist and physician Dr. Peter Pugliese. Based in Leesport, Pennsylvania. Formulated for estheticians and their clients, with a science depth that rivals medical-grade skincare without the prescription barrier.

• Fine Lines and Wrinkles,
• Loss of Firmness,
• Hyperpigmentation,
• Aging Skin

Aging, Mature, and Dull or Uneven Skin Types. Especially beneficial for those experiencing fine lines, wrinkles, loss of firmness, hyperpigmentation, uneven texture, and reduced radiance. Suitable for all skin types with aging concerns. Formulated for evening use, aligned with the skin's natural nocturnal repair cycle.

Amandola Milk Cleanser 2oz,
Serum 71 0.5oz,
Cyto-Comm 0.5oz,
Revita-Cyte Complex 2oz

Add the Vitamin C Reversal Serum to your AM routine alongside this kit. Serum 71 and Cyto-Comm both address the structural causes of aging at night, while Vitamin C in the morning provides the antioxidant defense that prevents new damage during the day. Morning protection and nighttime repair run on different biological clocks, and the full Circadia anti-aging protocol respects both.

AM Routine:

Cleanse with Amandola Milk Cleanser morning and evening. Dispense a dime-sized amount onto fingertips and apply to face in gentle circular motions. Rinse well and pat dry.

PM Routine:

Step 1: Cleanse with Amandola Milk Cleanser.
Step 2: Apply several drops of Serum 71 to face and neck after cleansing. Allow to absorb.
Step 3: Apply Cyto-Comm Serum after Serum 71. Allow to absorb.
Step 4: Apply Revita-Cyte Complex as the final PM step to rejuvenate, firm, and seal the regimen.

Note: This is a PM-focused regimen. Serum 71, Cyto-Comm, and Revita-Cyte Complex are all designed for evening use to align with the skin's natural nocturnal repair cycle. Always follow with SPF in the morning

Lactic and Mandelic Acids (Amandola Milk Cleanser): Dual alpha hydroxy acids that exfoliate the surface, inhibit tyrosinase to support a more even skin tone, and stimulate glycosaminoglycan production to support the skin's own moisture matrix.
Sweet Almond Oil and Oat Kernel Protein (Amandola Milk Cleanser): Nourishing and antioxidant-rich ingredients that condition and protect the skin during the cleansing step rather than leaving it feeling stripped.
Tranexamic Acid and Azelaic Acid (Serum 71): A clinically validated duo that addresses hyperpigmentation through different but complementary mechanisms. Tranexamic acid blocks the enzymatic production of excess melanin. Azelaic acid adds pore-refining, anti-inflammatory, and brightening support with excellent tolerability on sensitive skin.
Neodermyl / Copper Lysinate/Prolinate (Serum 71): A patented next-generation copper peptide clinically shown to stimulate collagen and elastin production at a higher efficacy than standard copper peptides. Addresses visible firmness and elasticity loss directly at the cellular level.
Magnesium Carboxymethyl Beta-Glucan (Serum 71): A second-generation beta-glucan with enhanced skin-fortifying and repair-stimulating activity that supports the skin's resilience and self-renewal processes.
Trifluoroacetyl Tripeptide-2 (Cyto-Comm): A specialized peptide that targets glycation, the molecular cross-linking of collagen that accelerates visible aging. Detoxifies the skin from glycating agents, protects biomolecules from glycation-induced inflammation, and helps prevent cell loss associated with elevated advanced glycation end-products.
Aminopropyl Ascorbyl Phosphate (Cyto-Comm): A stable, water-soluble Vitamin C derivative that delivers antioxidant protection and supports collagen synthesis.
Advanced Antioxidants, Peptides, and Mitochondrial Support (Revita-Cyte Complex): A multi-targeted evening complex that helps firm the skin, improve radiance, and restore youthful resilience through ingredients that support cellular energy production, collagen integrity, and Vitamin D expression.
Full Ingredient Lists:
Amandola Milk Cleanser 2oz: Aqua/Water, Cetearyl Ethylhexanoate, Caprylic/Capric Triglyceride, Triisononanoin, Pentylene Glycol, Ammonium Acryloyl Dimethyltaurate/Carboxyethyl Acrylate Crosspolymer, Cetearyl Alcohol, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Glyceryl Distearate, Avena Sativa (Oat) Kernel Protein, Mandelic Acid, Panthenol, Lactic Acid, Glyceryl Stearate, Caprylyl Glycol, 1,2-Hexanediol, Isopropyl Myristate, Ceteareth-20, Parfum/Fragrance, Tocopheryl Acetate, Xanthan Gum, Tetrasodium EDTA, Glycerin, Lysolecithin, Potassium Sorbate, Sodium Benzoate, Sodium Hydroxide, Benzaldehyde.
Serum 71 0.5oz: Aqua/Water, Propanediol, Mandelic Acid, Butylene Glycol, Tranexamic Acid, Phenoxyethanol, Sodium PCA, Hydroxyethylcellulose, Sodium Hydroxide, Azelaic Acid, Glycerin, Magnesium Carboxymethyl Beta-Glucan, Methylglucoside Phosphate, Copper Lysinate/Prolinate, Alcohol, Sodium Hydroxide.
Cyto-Comm 0.5oz: Aqua/Water, Aminopropyl Ascorbyl Phosphate, Pentylene Glycol, Sodium Hyaluronate, Acacia Senegal Gum, Glycerin, Osmanthus Fragrans Flower Extract, Caprylyl Glycol, Tetrasodium Glutamate Diacetate, Phenoxyethanol, Trifluoroacetyl Tripeptide-2, Dextran, Valine, Proline, Glycine, Alanine, Lysine Hydrochloride.
Revita-Cyte Complex 2oz: Full INCI list available on product packaging. Contains advanced antioxidants, next-generation peptides, and mitochondrial-supporting ingredients. (double-check this, the full INCI wasn't accessible from the brand site during research)